DJ Dave Lee Travis has been charged with 11 counts of indecent assault and one of sexual assault against alleged victims aged between 15 and 29.
The 68-year-old, whose real name is David Patrick Griffin, is accused of committing the offences between 1977 and 2007, the Crown Prosecution Service said.
Chief Crown Prosecutor for CPS London, Alison Saunders, said: "We have carefully considered the evidence gathered by the Metropolitan Police Service as part of Operation Yewtree in relation to David Patrick Griffin, who was initially arrested on November 15 2012 over allegations of sexual offences.
"Having completed our review, we have concluded that there is sufficient evidence and it is in the public interest for Mr Griffin to be charged with 11 counts of indecent assault and one of sexual assault. These date from 1977 to 2007 and relate to nine complainants aged between 15 and 29 at the time of the alleged offending."
He is due to appear at Westminster Magistrates' Court on August 23.
Prosecutors have decided that no further action should be taken in relation to seven separate allegations made against the DJ because there was not enough evidence.